Ethyl Acetoacetate → HCID 66746535, 화합물

반응식

[NH2:1][C:2]1[C:3]([C:24]#[N:25])=[C:4]([CH:21]=[CH:22][CH:23]=1)[O:5][CH2:6][C:7]([NH:10]C(=O)OCC1C=CC=CC=1)([CH3:9])[CH3:8].O=[C:27]([CH3:34])[CH2:28][C:29]([O:31][CH2:32][CH3:33])=[O:30]>>[NH2:25][C:24]1[C:3]2[C:2](=[CH:23][CH:22]=[CH:21][C:4]=2[O:5][CH2:6][C:7]([NH2:10])([CH3:8])[CH3:9])[N:1]=[C:27]([CH3:34])[C:28]=1[C:29]([O:31][CH2:32][CH3:33])=[O:30]

참가 물질

반응물 2

HCID 8868Ethyl Acetoacetate

HCID 66746504HCID 66746504, 화합물

생성물 1

HCID 66746535HCID 66746535, 화합물

실험 절차

Prepared as in Example 2a from benzyl 1-(3-amino-2-cyanophenoxy)-2-methylpropan-2-ylcarbamate (Example 24c) and ethyl 3-oxobutanoate as a yellow-brown solid (91%). 1H NR (400 MHz, DMSO-d6) δ 1.15 (s, 6H), 1.31 (t, J=4 Hz, 3H), 2.54 (s, 3H), 3.87 (s, 2H), 4.31 (q, J=4 Hz, 2H), 6.85 (d, J=4 Hz, 1H), 7.21 (d, J=4 Hz, 1H), 7.49 (t, J=8 Hz, 1H), 8.38 (brs, 2H). MS 318 (MH+).

출처 및 근거

ORD 기록: ord-1ddd38e4e36546f2bd3d295bab813183
출처 데이터셋: uspto-grants-2015_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09049878B2

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