Triethyl phosphite → Benzyl (diethoxyphosphoryl)acetate

HRID 2170517노트

반응식

[CH2:1]([O:8][C:9](=[O:12])[CH2:10]Br)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:13]([O:15][P:16]([O:20]CC)[O:17][CH2:18][CH3:19])[CH3:14]>>[CH2:1]([O:8][C:9](=[O:12])[CH2:10][P:16]([O:17][CH2:18][CH3:19])([O:15][CH2:13][CH3:14])=[O:20])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

반응물 2

HCID 31215Triethyl phosphite

HCID 62576Benzyl bromoacetate

생성물 1

HCID 281239Benzyl (diethoxyphosphoryl)acetate수율 80.3%

실험 절차

The mixture of bromo-acetic acid benzyl ester (229 g, 1.0 mol) and phosphorous acid triethyl ester (166 g, 1.0 mol) was stirred at reflux for 10 hrs and the solvent was evaporated in vacuo to give crude (diethoxy-phosphoryl)-acetic acid benzyl ester (230 g) which was directly used for next step.

후처리

temperatureat reflux for 10 hrs
customthe solvent was evaporated in vacuo

출처 및 근거

ORD 기록: ord-74ab55953b9748ec8c6d2eb897d01782
출처 데이터셋: uspto-grants-2015_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09051280B2

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