3,4-dihydro-2H-pyran → 2-[2-(4-Nitrophenoxy)ethoxy]oxane

HRID 2170534노트

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HRID 2170534 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:11][CH2:12][OH:13])=[CH:6][CH:5]=1)([O-:3])=[O:2].[O:14]1[CH:19]=[CH:18][CH2:17][CH2:16][CH2:15]1>C1(C)C=CC=CC=1>[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([O:10][CH2:11][CH2:12][O:13][CH:15]2[CH2:16][CH2:17][CH2:18][CH2:19][O:14]2)=[CH:8][CH:9]=1)([O-:3])=[O:2]

참가 물질

4

반응물 2

HCID 80803,4-dihydro-2H-pyranHCID 853812-(4-Nitrophenoxy)ethanol

생성물 1

HCID 108908362-[2-(4-Nitrophenoxy)ethoxy]oxane

시약·촉매·용매 1

HCID 1140Toluene용매

반응 조건

온도
60 °C

실험 절차

To a solution of 2-[(4-Nitrophenyl)oxy]ethanol (1 g, 5.4 mmol), in toluene (50 mL) was added 3,4-dihydro-2H-pyran (1.5 mL) and APTS (catalytic amount). The reaction was stirred at 60° C. for 3 hours. The dark solution was then concentrated and purified by flash chromatography using DCM/cyclohexane 30/70 as eluent. The title compound was obtained as an oil (1.33 g, 92%). LC: Rt: 3.12 min.

후처리

  1. concentrationThe dark solution was then concentrated
  2. custompurified by flash chromatography

출처 및 근거

ORD 기록
ord-8cf2f68ca8f346989f7d7ddb3fcfb7f9
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09051281B2

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