N-bromobutanimide → Methyl 1-(4-(bromomethyl)phenyl)cyclopropanecarboxylate

HRID 2170619노트

반응식

HRID 2170619 반응식
[C:1]1([CH3:14])[CH:6]=[CH:5][C:4]([C:7]2([C:10]([O:12][CH3:13])=[O:11])[CH2:9][CH2:8]2)=[CH:3][CH:2]=1.[Br:15]N1C(=O)CCC1=O>C(Cl)(Cl)(Cl)Cl.C(Cl)Cl.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>[Br:15][CH2:14][C:1]1[CH:2]=[CH:3][C:4]([C:7]2([C:10]([O:12][CH3:13])=[O:11])[CH2:9][CH2:8]2)=[CH:5][CH:6]=1

참가 물질

6

반응물 2

HCID 67184N-bromobutanimideHCID 57443305Methyl 1-(p-tolyl)cyclopropanecarboxylate

생성물 1

HCID 57443306Methyl 1-(4-(bromomethyl)phenyl)cyclopropanecarboxylate수율 97.7%

시약·촉매·용매 3

HCID 7187Benzoyl Peroxide촉매HCID 5943Carbon Tetrachloride용매HCID 6344Dichloromethane용매

실험 절차

To a solution of methyl 1-(p-tolyl)cyclopropanecarboxylate (622 mg, 3.27 mmol) in carbon tetrachloride (16 mL) was added N-bromosuccinimide (611 mg) followed by benzoyl peroxide (40 mg). The resulting solution was heated at reflux overnight, and then diluted with methylene chloride. The mixture was washed with brine, dried on MgSO4, and concentrated to afford a colorless oil (860 mg, 97%).

후처리

  1. temperatureThe resulting solution was heated
  2. temperatureat reflux overnight
  3. washThe mixture was washed with brine
  4. customdried on MgSO4
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-1017ed48bbb74551815cae6c241a20de
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09051265B2

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