Diisopropylethylamine → HCID 71075406, 화합물

HRID 2170628노트

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HRID 2170628 반응식
[CH3:1][O:2][C:3](=[O:27])[CH2:4][O:5][C:6]1[CH:26]=[CH:25][C:9]([CH2:10][N:11]2[C:19]3[C:14](=[CH:15][C:16]([C:20](O)=[O:21])=[CH:17][CH:18]=3)[C:13]([CH3:23])=[C:12]2[CH3:24])=[CH:8][CH:7]=1.Cl.[CH:29]1([C:32]2[CH:33]=[C:34]([C@@H:38]([NH2:40])[CH3:39])[CH:35]=[CH:36][CH:37]=2)[CH2:31][CH2:30]1.CCN(C(C)C)C(C)C.CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F>C(Cl)Cl.C(OCC)(=O)C>[CH:29]1([C:32]2[CH:33]=[C:34]([C@@H:38]([NH:40][C:20]([C:16]3[CH:15]=[C:14]4[C:19](=[CH:18][CH:17]=3)[N:11]([CH2:10][C:9]3[CH:8]=[CH:7][C:6]([O:5][CH2:4][C:3]([O:2][CH3:1])=[O:27])=[CH:26][CH:25]=3)[C:12]([CH3:24])=[C:13]4[CH3:23])=[O:21])[CH3:39])[CH:35]=[CH:36][CH:37]=2)[CH2:31][CH2:30]1

참가 물질

7

반응물 4

HCID 81531DiisopropylethylamineHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 71075337HCID 71075337, 화합물HCID 86674582HCID 86674582, 화합물

생성물 1

HCID 71075406HCID 71075406, 화합물수율 102.1%

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 8857Ethyl Acetate용매

실험 절차

To a solution of the 1-(4-(2-methoxy-2-oxoethoxy)benzyl)-2,3-dimethyl-1H-indole-5-carboxylic acid (50 mg, 0.14 mmol) in DCM (1 mL) was added the (S)-1-(3-cyclopropylphenyl)ethanamine hydrochloride (28 mg), DIEA (73 μL) and HATU (53 mg). The reaction mixture was allowed to stir at rt for 30 min, and then was diluted by ethyl acetate. The resulting mixture was washed with a 0.5 N HCl solution, a saturated solution of NaHCO3, and brine, dried on MgSO4, and concentrated to afford a yellow oil (73 mg) which was directly used without further purification. ESI-MS (m/z): 497 [M+H]+

후처리

  1. washThe resulting mixture was washed with a 0.5 N HCl solution
  2. dry with materiala saturated solution of NaHCO3, and brine, dried on MgSO4
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-635ec30f66e24bb89e15eace0a5c1027
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09051265B2

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