Triphenylphosphine → HCID 86674596, 화합물

HRID 2170712노트

반응식

HRID 2170712 반응식
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([N:10]2[C:18]3[C:13](=[CH:14][C:15]([C:19]([O:21][CH2:22][CH:23]=[CH2:24])=[O:20])=[CH:16][CH:17]=3)[C:12]([CH3:25])=[C:11]2[CH3:26])[CH3:9])=[CH:4][CH:3]=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.O[C@H:47]([CH3:52])[C:48]([O:50][CH3:51])=[O:49].CC(OC(/N=N/C(OC(C)C)=O)=O)C>C1COCC1>[CH3:51][O:50][C:48](=[O:49])[C@@H:47]([O:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]([N:10]2[C:18]3[C:13](=[CH:14][C:15]([C:19]([O:21][CH2:22][CH:23]=[CH2:24])=[O:20])=[CH:16][CH:17]=3)[C:12]([CH3:25])=[C:11]2[CH3:26])[CH3:9])=[CH:6][CH:7]=1)[CH3:52]

참가 물질

6

반응물 4

HCID 11776TriphenylphosphineHCID 637514(+)-Methyl lactateHCID 5363146Diisopropyl azodicarboxylateHCID 86674595HCID 86674595, 화합물

생성물 1

HCID 86674596HCID 86674596, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To allyl 1-(1-(4-hydroxyphenyl)ethyl)-2,3-dimethyl-1H-indole-5-carboxylate (0.286 g, 0.82 mmol) in THF (0.8 mL) in an ice bath was added triphenylphosphine (0.28 g, 1.07 mmol) and then (R)-methyl 2-hydroxypropanoate (0.093 mL, 0.98 mmol). DIAD (0.24 mL, 1.23 mmol) was added dropwise to the cold solution. The mixture was stirred at room temperature for 16 hr. The solvent was removed and the residue was purified by silica gel chromatography to obtain the title compound. ESI-MS (m/z): 436 [M+H]+.

후처리

  1. customThe solvent was removed
  2. customthe residue was purified by silica gel chromatography

출처 및 근거

ORD 기록
ord-1ddeef3d6a3d4cc9a90064cb899531cc
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09051265B2

반응 노트

불러오는 중…