Uridine Diphosphate → Uridine 5'-triphosphate

HRID 217098

반응식

HRID 217098 반응식
[P:1]([O:9][CH2:10][C@H:11]1[O:15][C@@H:14]([N:16]2[CH:23]=[CH:22][C:20](=[O:21])[NH:19][C:17]2=[O:18])[C@H:13]([OH:24])[C@@H:12]1[OH:25])([O:4][P:5]([OH:8])([OH:7])=[O:6])(=[O:3])[OH:2].[Cl-].[Mg+2].[Cl-].C(N(CCCC)CCCC)CCC>CN(C)C=O>[CH:22]1[C:20](=[O:21])[NH:19][C:17](=[O:18])[N:16]([C@@H:14]2[O:15][C@H:11]([CH2:10][O:9][P:1]([O:4][P:5]([O:8][P:1]([OH:4])([OH:3])=[O:2])([OH:7])=[O:6])([OH:2])=[O:3])[C@@H:12]([OH:25])[C@H:13]2[OH:24])[CH:23]=1

참가 물질

5

반응물 3

HCID 6031Uridine DiphosphateHCID 7622TributylamineHCID 5360315Magnesium Chloride

생성물 1

HCID 6133Uridine 5'-triphosphate수율 50.5%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매3회

실험 절차

A 0.154 M dimethylformamide solution of uridine 5′-diphosphate (UDP) tributylamine salt (584 μL, 90.0 μmol) and a 0.45 M dimethylformamide solution of anhydrous magnesium chloride (200 μL, 90.0 μmol) were added to a 0.15 M dimethylformamide solution of cUTP tributylamine salt (500 μL, 75.0 μmol), and the mixture was stirred at room temperature for 72 hours. The resultant reaction mixture was analyzed through HPLC (262 nm). As a result, Up5U (i.e., target product) was found to be produced from UTP at a synthesis yield of 50.5%.

후처리

  1. customThe resultant reaction mixture

출처 및 근거

ORD 기록
ord-b779d8eddbca477eb784101004ed9b6e
출처 데이터셋
uspto-grants-2012_06
특허 번호
US08193338B2

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