Potassium Carbonate → HCID 67465591, 화합물

HRID 2171184노트

반응식

HRID 2171184 반응식
[Br:1][C:2]1[C:3]([O:11][CH2:12][O:13][CH3:14])=[C:4]([OH:10])[C:5]([O:8][CH3:9])=[CH:6][CH:7]=1.C(=O)([O-])[O-].[K+].[K+].[CH:21]1([CH2:24]Br)[CH2:23][CH2:22]1>C(#N)C>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[C:4]([O:10][CH2:24][CH:21]2[CH2:23][CH2:22]2)[C:3]=1[O:11][CH2:12][O:13][CH3:14]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 81503BromomethylcyclopropaneHCID 67466846HCID 67466846, 화합물

생성물 1

HCID 67465591HCID 67465591, 화합물수율 38.5%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

To a stirring solution of 3-bromo-6-methoxy-2-(methoxymethoxy)phenol (12 g, 0.045 mol) in acetonitrile (100 mL) at 0° C. was added potassium carbonate (18 g, 0.135 mol) and cyclopropylmethyl bromide (9 g, 0.067 mol) and the resultant reaction mixture was stirred for 1 h at RT. The reaction mixture was filtered through celite and the filtrate was concentrated under reduced pressure. The residue was purified by column chromatography (silica gel, 0-12% ethyl acetate in pet ether) to afford 1-Bromo-3-(cyclopropylmethoxy)-4-methoxy-2-(methoxymethoxy)benzene as a solid (5.5 g, 38%).

후처리

  1. customthe resultant reaction mixture
  2. filtrationThe reaction mixture was filtered through celite
  3. concentrationthe filtrate was concentrated under reduced pressure
  4. customThe residue was purified by column chromatography (silica gel, 0-12% ethyl acetate in pet ether)

출처 및 근거

ORD 기록
ord-c5257943ab174d788140b7b57606f356
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09051290B2

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