Ethanolamine → HCID 59312917, 화합물

HRID 2171502노트

반응식

HRID 2171502 반응식
Cl[C:2]1[N:7]2[CH:8]=[CH:9][N:10]=[C:6]2[CH:5]=[C:4]([C:11]2[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][C:12]=2[Cl:18])[N:3]=1.[NH2:19][CH2:20][CH2:21][OH:22]>CS(C)=O>[Cl:18][C:12]1[CH:13]=[C:14]([Cl:17])[CH:15]=[CH:16][C:11]=1[C:4]1[N:3]=[C:2]([NH:19][CH2:20][CH2:21][OH:22])[N:7]2[CH:8]=[CH:9][N:10]=[C:6]2[CH:5]=1

참가 물질

4

반응물 2

HCID 700EthanolamineHCID 59312932HCID 59312932, 화합물

생성물 1

HCID 59312917HCID 59312917, 화합물

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

실험 절차

2-{[7-(2,4-Dichlorophenyl)imidazo[1,2-c]pyrimidin-5-yl]amino}ethanol (Example 49A) is prepared in analogy to Example 36A from 5-chloro-7-(2,4-dichlorophenyl)imidazo[1,2-c]-pyrimidine (Example 6A) (200 mg, 0.7 mmol) and 2-aminoethanol (82 mg, 1.3 mmol) in DMSO (80° C., 4 h). Removal of the solvent results in a crude product which is precipitated from dichloromethane. The product is filtered off with suction and dried. 216 mg (99% of theory) of product are obtained as a solid.

후처리

  1. customRemoval of the solvent

출처 및 근거

ORD 기록
ord-52280d459f0148bcb30b6f222f7dccb5
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09051323B2

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