Ethanolamine → HCID 59312971, 화합물

HRID 2171517노트

반응식

HRID 2171517 반응식
[NH2:1][C:2]1[N:3]=[C:4](S(C)(=O)=O)[S:5][C:6]=1[C:7]#[N:8].[NH2:13][CH2:14][CH2:15][OH:16]>CS(C)=O>[NH2:1][C:2]1[N:3]=[C:4]([NH:13][CH2:14][CH2:15][OH:16])[S:5][C:6]=1[C:7]#[N:8]

참가 물질

4

반응물 2

HCID 700EthanolamineHCID 198350775-Thiazolecarbonitrile, 4-amino-2-(methylsulfonyl)-

생성물 1

HCID 59312971HCID 59312971, 화합물수율 116.8%

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

실험 절차

Example 89A is prepared in analogy to Example 48A from 4-amino-2-(methylsulphonyl)-1,3-thiazole-5-carbonitrile (Example 18A) (499 mg, 2.45 mmol) and 2-aminoethanol (300 mg, 4.91 mmol) in DMSO (80° C., 20 h). Removal of the solvent results in a crude product 527 mg (50% of theory) which is employed without further purification.

후처리

  1. customRemoval of the solvent

출처 및 근거

ORD 기록
ord-e9c3dd3ce4b64368a28748ec3e97fd3c
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09051323B2

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