Hydrochloric Acid → HCID 66911325, 화합물

HRID 2171531노트

반응식

HRID 2171531 반응식
[NH2:1][C:2]1[N:7]=[C:6]([NH:8][CH2:9][CH2:10][NH:11]C(=O)OC(C)(C)C)[CH:5]=[CH:4][C:3]=1[C:19]#[N:20].[ClH:21]>O1CCOCC1>[ClH:21].[ClH:21].[NH2:1][C:2]1[C:3]([C:19]#[N:20])=[CH:4][CH:5]=[C:6]([NH:8][CH2:9][CH2:10][NH2:11])[N:7]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 57911763tert-Butyl{2-[(6-amino-5-cyanopyridin-2-yl)amino]ethyl}carbamate

생성물 1

HCID 66911325HCID 66911325, 화합물

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

6.76 g (24.38 mmol) of tert-butyl {2-[(6-amino-5-cyanopyridin-2-yl)amino]ethyl}carbamate (Example 110A) are dissolved in 122 ml of 4N hydrogen chloride in dioxane and stirred for 30 min. The reaction mixture is concentrated to one half, and an equal portion of diethyl ether is added. The reaction mixture is stirred for 20 min, and the product is filtered off and washed with diethyl ether. 5.43 g (89% of theory) of the product are obtained as a solid.

후처리

  1. concentrationThe reaction mixture is concentrated to one half
  2. additionan equal portion of diethyl ether is added
  3. stirringThe reaction mixture is stirred for 20 min
  4. filtrationthe product is filtered off
  5. washwashed with diethyl ether
  6. custom5.43 g (89% of theory) of the product are obtained as a solid

출처 및 근거

ORD 기록
ord-eca5cbf0c2d340718c4a7a2de9726773
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09051323B2

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