Water → 4-(Trifluoromethyl)cyclohexane-1-carbaldehyde
반응식
[F:1][C:2]([F:12])([F:11])[C@@H:3]1[CH2:8][CH2:7][C@H:6]([CH2:9][OH:10])[CH2:5][CH2:4]1.I(C1C=CC=CC=1C(O)=O)(=O)=O.O.C(OCC)(=O)C>CS(C)=O>[F:1][C:2]([F:11])([F:12])[CH:3]1[CH2:4][CH2:5][CH:6]([CH:9]=[O:10])[CH2:7][CH2:8]1참가 물질
6
실험 절차
After dissolving [cis-4-(trifluoromethyl)cyclohexyl]methanol (2.04 g, 10.2 mmol) in dimethylsulfoxide (30 ml), 2-iodoxybenzoic acid (4.00 g, 14.3 mmol) was added thereto and stirred at room temperature overnight. Water and ethyl acetate were added to the reaction mixture, the insoluble matter was removed by filtration, and then the filtrate was separated into layers. The organic layer was washed with water and a saturated sodium chloride aqueous solution, dried over sodium sulfate, and concentrated to afford the title compound as a colorless oil (2.3 g, 100%).
후처리
- additionwas added
- customthe insoluble matter was removed by filtration
- customthe filtrate was separated into layers
- washThe organic layer was washed with water
- dry with materiala saturated sodium chloride aqueous solution, dried over sodium sulfate
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-e8e52f2b652e41d387388aa0b2345957
- 출처 데이터셋
- uspto-grants-2015_06
- 특허 번호
- US09051333B2
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