Water → 2-Methyl-2-phenylpropan-1-amine

HRID 2172718노트

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HRID 2172718 반응식
[H-].[Al+3].[Li+].[H-].[H-].[H-].[CH3:7][C:8]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)([CH3:11])[C:9]#[N:10].O.[OH-].[Na+]>O1CCCC1>[CH3:11][C:8]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)([CH3:7])[CH2:9][NH2:10]

참가 물질

6

반응물 4

HCID 962Water2회HCID 14798Sodium HydroxideHCID 27975912-Methyl-2-phenylpropanenitrileHCID 21226445Aluminium lithium hydride

생성물 1

HCID 2106022-Methyl-2-phenylpropan-1-amine수율 89.3%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

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온도
80 °C

실험 절차

Powdered lithium aluminum hydride (137 mg, 3.61 mmol) was added portionwise to a solution of 2-methyl-2-phenylpropanenitrile (436 mg, 3.00 mmol) in tetrahydrofuran (20 mL). The resulting mixture was stirred at 80° C. overnight. The reaction was then cooled to 0° C. and water (66 μL, 3.7 mmol), 10% sodium hydroxide (1.44 g, 3.6 mmol) and water (195 μL, 10.8 mmol), respectively, were added dropwise into the reaction mixture. The suspension was filtered through anhydrous magnesium sulfate and the solution was concentrated under vacuum to give 2-methyl-2-phenylpropan-1-amine (400 mg) as a yellow oil, which was used for the next step without further purification.

후처리

  1. temperatureThe reaction was then cooled to 0° C.
  2. filtrationThe suspension was filtered through anhydrous magnesium sulfate
  3. concentrationthe solution was concentrated under vacuum

출처 및 근거

ORD 기록
ord-6f2c8001aeef46d98bbcb58c5971a5af
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09056852B2

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