2',3',4'-Trichloroacetophenone → 1-(2,3,4-Trichlorophenyl)ethan-1-ol

HRID 21736노트

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HRID 21736 반응식
[Cl:1][C:2]1[C:7]([Cl:8])=[C:6]([Cl:9])[CH:5]=[CH:4][C:3]=1[C:10](=[O:12])[CH3:11].[BH4-].[Na+]>CO>[Cl:1][C:2]1[C:7]([Cl:8])=[C:6]([Cl:9])[CH:5]=[CH:4][C:3]=1[CH:10]([OH:12])[CH3:11]

참가 물질

4

반응물 2

HCID 261322',3',4'-TrichloroacetophenoneHCID 4311764Sodium borohydride

생성물 1

HCID 167691051-(2,3,4-Trichlorophenyl)ethan-1-ol수율 99.4%

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
25 °C

실험 절차

In methanol (284 ml)is suspended 2',3',4'-trichloroacetophenone (94.7 g), and thereto is added sodium borohydride (7.6 g) at 15° C.-25° C. The mixture is stirred at 25° C. for two hours, and evaporated to remove the methanol. To the residue is added 2N hydrochloric acid (110 ml), and the mixture is extracted with ethyl acetate. The organic layer is washed with water, dried, and evaporated to remove the solvent to give crude 1-(2,3,4-trichlorophenyl)ethanol (95 g).

후처리

  1. customevaporated
  2. customto remove the methanol
  3. additionTo the residue is added 2N hydrochloric acid (110 ml)
  4. extractionthe mixture is extracted with ethyl acetate
  5. washThe organic layer is washed with water
  6. customdried
  7. customevaporated
  8. customto remove the solvent

출처 및 근거

ORD 기록
ord-04631bac06bc4c08aad218d874f15c39
출처 데이터셋
uspto-grants-1995_06
특허 번호
US05424446

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