Methanol → Methyl 2,4,6-trimethylbenzene-1-sulfonate

HRID 2173894노트

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HRID 2173894 반응식
[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[C:4]([CH3:9])[C:3]=1[S:10](Cl)(=[O:12])=[O:11].[OH-:14].[Na+].[CH3:16]O>>[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[C:4]([CH3:9])[C:3]=1[S:10]([O:12][CH3:16])(=[O:14])=[O:11]

참가 물질

4

반응물 3

HCID 887Methanol2회HCID 130462-Mesitylenesulfonyl chlorideHCID 14798Sodium Hydroxide

생성물 1

HCID 13310198Methyl 2,4,6-trimethylbenzene-1-sulfonate수율 96%

실험 절차

to a solution of 2,4,6-trimethylbenzene-1-sulfonyl chloride (30 g, 0.136 mol) dissolved in methanol (350 ml), a solution of NaOH (5.49 g, 0.136 mol, 1 equiv.) dissolved in methanol (60 ml) was added dropwise. White NaCl was precipitated and filtered to remove NaCl, and the filtered solution was evaporated, followed by extraction with water and methylene chloride, and the organic layer was obtained, evaporated the solvent therefrom and then dried in a vacuum, affording a white solid at a yield of 96%.

후처리

  1. additionwas added dropwise
  2. customWhite NaCl was precipitated
  3. filtrationfiltered
  4. customto remove NaCl
  5. customthe filtered solution was evaporated
  6. extractionfollowed by extraction with water and methylene chloride
  7. customthe organic layer was obtained
  8. customevaporated the solvent
  9. customdried in a vacuum
  10. customaffording a white solid at a yield of 96%

출처 및 근거

ORD 기록
ord-7c0eebe1760e4946aaf165df84aa45b7
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09057929B2

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