Water → 3-Bromo-5-(4-methylsulfonylphenyl)pyrazin-2-amine

HRID 2174654노트

반응식

HRID 2174654 반응식
C1C(=O)N([Br:8])C(=O)C1.[CH3:9][S:10]([C:13]1[CH:18]=[CH:17][C:16]([C:19]2[N:20]=[CH:21][C:22]([NH2:25])=[N:23][CH:24]=2)=[CH:15][CH:14]=1)(=[O:12])=[O:11].O>CN(C=O)C>[Br:8][C:21]1[C:22]([NH2:25])=[N:23][CH:24]=[C:19]([C:16]2[CH:15]=[CH:14][C:13]([S:10]([CH3:9])(=[O:11])=[O:12])=[CH:18][CH:17]=2)[N:20]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 67184N-bromobutanimideHCID 580843845-[4-(Methylsulfonyl)phenyl]-2-pyrazinamine

생성물 1

HCID 580843703-Bromo-5-(4-methylsulfonylphenyl)pyrazin-2-amine수율 84%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

NBS (1.807 g, 10.15 mmol) was added to a stirred solution of 5-(4-methylsulfonylphenyl)pyrazin-2-amine (2.53 g, 10.15 mmol) in DMF (40 mL) and the reaction stirred at ambient temperature for 15 hours. The reaction mixture was added slowly to rapidly stirring water and the resultant precipitate was isolated by filtration and dried in vacuo to give the sub-title compound as a beige solid that was used without further purification (2.8 g, 84% Yield).

출처 및 근거

ORD 기록
ord-a0da0d13b1674a2f8852c66c22ec0d2c
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09062008B2

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