Benzyl Alcohol → 3-(Benzyloxy)-5-bromopyrazin-2-amine
반응식
[H-].[Na+].[C:3]1([CH2:9][OH:10])[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.Br[C:12]1[C:13]([NH2:19])=[N:14][CH:15]=[C:16]([Br:18])[N:17]=1>C1COCC1>[CH2:9]([O:10][C:12]1[C:13]([NH2:19])=[N:14][CH:15]=[C:16]([Br:18])[N:17]=1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1참가 물질
5
실험 절차
NaH, 60% in oil (36.98 mg, 0.9247 mmol) was added to a solution of phenylmethanol (100 mg, 0.9247 mmol) in THF (5 mL). The mixture was stirred at ambient temperature for 20 minutes and then 3,5-dibromopyrazin-2-amine (116.9 mg, 0.4624 mmol) was added and the reaction mixture heated under microwave conditions for 20 minutes at 80° C.
후처리
- temperaturethe reaction mixture heated under microwave conditions for 20 minutes at 80° C.
출처 및 근거
- ORD 기록
- ord-f75c81a92d4e40a2862f900d1aafafa8
- 출처 데이터셋
- uspto-grants-2015_06
- 특허 번호
- US09062008B2
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