Diisopropylethylamine → Ethyl (βR)-β-[(2-cyclopropyl-5-nitro-4-pyrimidinyl)amino]benzenepropanoate

HRID 2175201

반응식

HRID 2175201 반응식
Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][N:5]=[C:4]([CH:11]2[CH2:13][CH2:12]2)[N:3]=1.Cl.[CH2:15]([O:17][C:18](=[O:28])[CH2:19][C@@H:20]([NH2:27])[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[CH3:16].CCN(C(C)C)C(C)C>CN(C=O)C.C(OCC)(=O)C>[CH2:15]([O:17][C:18](=[O:28])[CH2:19][C@@H:20]([NH:27][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][N:5]=[C:4]([CH:11]2[CH2:13][CH2:12]2)[N:3]=1)[C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1)[CH3:16]

참가 물질

6

반응물 3

HCID 81531DiisopropylethylamineHCID 2734508ethyl (3R)-3-amino-3-phenylpropanoate hydrochlorideHCID 56773419HCID 56773419, 화합물

생성물 1

HCID 58497407Ethyl (βR)-β-[(2-cyclopropyl-5-nitro-4-pyrimidinyl)amino]benzenepropanoate

시약·촉매·용매 2

HCID 6228Dimethylformamide용매HCID 8857Ethyl Acetate용매

실험 절차

To a solution of 4-Chloro-2-cyclopropyl-5-nitro-pyrimidine (597 mg, 3 mmol) in DMF (10 ml) was added (R)-3-Amino-3-phenyl-propionic acid ethyl ester hydro chloride (582 mg, 3 mmol). The mixture was stirred on ice for 5 minutes the DIPEA (580 mg, 4.5 mmol) was added. The solution was stirred at room temperature for one hour. TLC showed disappearance of the starting material. The reaction mixture was diluted with ethyl acetate, washed with water, dried over MgSO4, filtered, evaporated to dryness to give oil, which was used as such for the next step.

후처리

  1. additionwas added
  2. washwashed with water
  3. dry with materialdried over MgSO4
  4. filtrationfiltered
  5. customevaporated to dryness
  6. customto give oil, which

출처 및 근거

ORD 기록
ord-9c9de4620c994ebb884a5a6e39191328
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09062056B2

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