Ethyl Glycolate → Ethyl 2-((4-nitrophenoxy)carbonyloxy)acetate

반응식

[C:1](=O)([O:11][C:12]1[CH:17]=[CH:16][C:15]([N+:18]([O-:20])=[O:19])=[CH:14][CH:13]=1)[O:2]CC1C=CC=C(Br)C=1.BrC1C=C(CO)C=CC=1.[OH:31][CH2:32][C:33]([O:35][CH2:36][CH3:37])=[O:34]>>[N+:18]([C:15]1[CH:16]=[CH:17][C:12]([O:11][C:1]([O:31][CH2:32][C:33]([O:35][CH2:36][CH3:37])=[O:34])=[O:2])=[CH:13][CH:14]=1)([O-:20])=[O:19]

참가 물질

반응물 3

HCID 12184Ethyl Glycolate

HCID 851413-Bromobenzyl alcohol

HCID 867125803-Bromobenzyl 4-nitrophenyl carbonate

생성물 1

HCID 69126482Ethyl 2-((4-nitrophenoxy)carbonyloxy)acetate

실험 절차

The title compound was prepared using a procedure analogous to 3-bromobenzyl 4-nitrophenyl carbonate except that (3-bromophenyl)methanol was replaced with ethyl 2-hydroxyacetate. LCMS, [M+Na]+=292.0. 1H NMR (400 MHz, CDCl3) δ 8.24 (d, J=9.2 Hz, 2H), 7.37 (d, J=9.2 Hz, 2H), 4.72 (s, 2H), 4.25 (q, J=7.2 Hz, 2H), 1.28 (t, J=7.1 Hz, 3H).

출처 및 근거

ORD 기록: ord-07c9f0c70cd44b0c84d4665c98dc0f3f
출처 데이터셋: uspto-grants-2015_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09062028B2

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