6-Amino-3-chloropyridazine → HCID 178484245, 화합물

HRID 2176619

반응식

HRID 2176619 반응식
[Cl:1][C:2]1[N:7]=[N:6][C:5]([NH2:8])=[CH:4][CH:3]=1.CO[CH:11](OC)[N:12]([CH3:14])[CH3:13]>>[Cl:1][C:2]1[N:7]=[N:6][C:5](/[N:8]=[CH:11]/[N:12]([CH3:14])[CH3:13])=[CH:4][CH:3]=1

참가 물질

3

반응물 2

HCID 216436-Amino-3-chloropyridazineHCID 78373Dimethylformamide dimethyl acetal

생성물 1

HCID 178484245HCID 178484245, 화합물수율 82.9%

반응 조건

온도
110 °C

실험 절차

A 500 mL RB flask was charged with 6-chloropyridazin-3-amine (10.0 g, 77.2 mmol) and dimethoxy-N,N-dimethylmethanamine (206 ml, 1544 mmol), equipped with a reflux condenser, then heated to 110° C. for 3 hours then left at room temperature for 16 hours. The precipitate was collected by filtration. The mother liquor was concentrated down to give an yellow solid, which was triturated with EtOAc and collected. The solids were combined to give (E)-N′-(6-chloropyridazin-3-yl)-N,N-dimethylformamidine (11.81 g, 82.9% yield) as a white solid

후처리

  1. customequipped with a reflux condenser
  2. filtrationThe precipitate was collected by filtration
  3. concentrationThe mother liquor was concentrated down
  4. customto give an yellow solid, which
  5. customwas triturated with EtOAc
  6. customcollected

출처 및 근거

ORD 기록
ord-866037ccb2c548d89a4cadf36b178b9f
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09066954B2

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