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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 2176779생성일: 2026년 10월 26일

3-(Methylcarbamoyl)propanoic acid → (3aR,4S,7aR)-methyl 4-(4-(methylamino)-4-oxobutanoyloxy)-4-(m-tolylethynyl)octahydro-1H-indole-1-carboxylate

https://huagongshe.com/reaction/2176779

반응식

참여 물질

역할이름HCID투입량
반응물3-(Methylcarbamoyl)propanoic acidHCID 292050—
반응물(3aS,4R,7aS)-4-hydroxy-4-m-tolylethynyl-octahydro-indole-1-carboxylic acid methyl esterHCID 68276168—
생성물(3aR,4S,7aR)-methyl 4-(4-(methylamino)-4-oxobutanoyloxy)-4-(m-tolylethynyl)octahydro-1H-indole-1-carboxylateHCID 86702180—

반응 단계

Synthesis in analogy to the General Method 1 starting from (3aS,4R,7aS)-4-hydroxy-4-m-tolylethynyl-octahydro-indole-1-carboxylic acid methyl ester and N-methylsuccinamic acid to yield (3aR,4S,7aR)-methyl 4-(4-(methylamino)-4-oxobutanoyloxy)-4-(m-tolylethynyl)octahydro-1H-indole-1-carboxylate. MS [M+H]=427; RT=1.06 min; UPLC Method I

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US09067881B2
출처 데이터셋uspto-grants-2015_06
ORD IDord-dcf85e8d928040f58183a4343805165e
출처 메모uspto-grants-2015_06