Water → (3,6-Dichloropyridazin-4-yl)diethylamine

HRID 217704

반응식

HRID 217704 반응식
[Cl:1][C:2]1[N:3]=[N:4][C:5]([Cl:9])=[CH:6][C:7]=1Cl.[CH2:10]([NH:12][CH2:13][CH3:14])[CH3:11].O.CC(=O)OCC>C1(C)C=CC=CC=1>[Cl:1][C:2]1[N:3]=[N:4][C:5]([Cl:9])=[CH:6][C:7]=1[N:12]([CH2:13][CH3:14])[CH2:10][CH3:11]

참가 물질

6

반응물 4

HCID 962WaterHCID 8021DiethylamineHCID 8857Ethyl AcetateHCID 951233,4,6-Trichloropyridazine

생성물 1

HCID 58136930(3,6-Dichloropyridazin-4-yl)diethylamine

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

3,4,6-Trichloropyridazine (2 g) and diethylamine (2.4 ml) were initially charged in toluene (10 ml) and left to stand at RT for 3 days. Then the mixture was admixed with water and EA, and the EA phase was removed. The EA phase was washed three times with water, dried over magnesium sulfate, filtered and concentrated. The residue was purified using silica gel (70 g cartridge, n-heptane/EA gradient 0-50% within 60 min). 1.1 g of the title compound were obtained.

후처리

  1. waitleft
  2. customthe EA phase was removed
  3. washThe EA phase was washed three times with water
  4. dry with materialdried over magnesium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated
  7. customThe residue was purified
  8. customsilica gel (70 g cartridge, n-heptane/EA gradient 0-50% within 60 min)

출처 및 근거

ORD 기록
ord-8b427b2e1e5a481394b1b715a71e768f
출처 데이터셋
uspto-grants-2012_06
특허 번호
US08198272B2

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