HCID 59438495, 화합물 → HCID 59438445, 화합물

HRID 2177494노트

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HRID 2177494 반응식
[CH3:1][N:2]1[CH2:7][CH2:6][CH2:5][C:4]([N+:14]([O-])=O)([C:8]2[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=2)[CH2:3]1>C1COCC1.[Ni]>[CH3:1][N:2]1[CH2:7][CH2:6][CH2:5][C:4]([NH2:14])([C:8]2[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=2)[CH2:3]1

참가 물질

4

반응물 1

HCID 59438495HCID 59438495, 화합물

생성물 1

HCID 59438445HCID 59438445, 화합물수율 100.1%

시약·촉매·용매 2

HCID 935Nickel촉매HCID 8028Tetrahydrofuran용매

반응 조건

온도
0 °C

실험 절차

To a 0° C. cooled solution of 52 mg (0.235 mmol) rac-1-Methyl-3-nitro-1,2,3,4,5,6-hexahydro-[3,4′]bipyridinyl in 2.0 ml THF were added 150 ul of Raney Nickel (50% in water). The mixture was stirred at 0° C. under a hydrogen atmosphere for 7 hours. The catalyst was filtered and the filtrate was concentrated in vacuo to provide 45 mg (88%) of the title compound as a light yellow oil. MS (m/e): 192.4 (M+H).

후처리

  1. filtrationThe catalyst was filtered
  2. concentrationthe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-104134f2fd98461a8c44f87dbba9999f
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09067911B2

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