[OH:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([N+:11]([O-:13])=[O:12])[C:9]=1[OH:10])[CH:5]=[O:6].[C:14]([O-])([O-])=O.[K+].[K+].Br[CH2:21][CH2:22][CH3:23].C(O[CH2:28][CH3:29])(=O)C>CN(C=O)C>[N+:11]([C:8]1[CH:7]=[C:4]([CH:3]=[C:2]([O:1][CH2:14][CH2:28][CH3:29])[C:9]=1[O:10][CH2:21][CH2:22][CH3:23])[CH:5]=[O:6])([O-:13])=[O:12]To a solution of 3,4-dihydroxy-5-nitrobenzaldehyde (400 mg, 2.185 mmol) in DMF (5 mL) was added K2CO3 (603 mg, 4.37 mmol) and 1-bromopropane (0.5 mL, excess), and the reaction was stirred at 80° C. overnight. Ethyl acetate (100 mL) was added and was washed with 2N aqueous HCl solution (20 mL×1), brine (20 mL×3), dried over Na2SO4, filtered, concentrated. The residue was purified by column chromatography (192 mg, yield: 32.91%).
불러오는 중…
