Water → p-((1-Oxoallyl)amino)benzoic acid

HRID 2178185

반응식

HRID 2178185 반응식
[NH2:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][CH:3]=1.[C:11](Cl)(=[O:14])[CH:12]=[CH2:13].O>CN(C=O)C.N1C=CC=CC=1>[C:11]([NH:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][CH:3]=1)(=[O:14])[CH:12]=[CH2:13]

참가 물질

6

반응물 3

HCID 962WaterHCID 9784-Aminobenzoic AcidHCID 13140Acryloyl chloride

생성물 1

HCID 84866p-((1-Oxoallyl)amino)benzoic acid수율 94.2%

시약·촉매·용매 2

HCID 1049Pyridine용매HCID 6228Dimethylformamide용매

실험 절차

A solution of 4-aminobenzoic acid (1.40 g, 10 mmol) in DMF (10 mL) and pyridine (0.5 ml) was cooled to 0° C. To this solution was added of acryloyl chloride (0.94 g, 10 mmol) and the resulting mixture was stirred for 3 hours. The mixture was poured into 200 ml of water and the white solid obtained was filtered, washed with water and ether. Drying under high vacuum provided 1.8 g of the desired product which was used in the next step without purification.

후처리

  1. customthe white solid obtained
  2. filtrationwas filtered
  3. washwashed with water and ether
  4. customDrying under high vacuum

출처 및 근거

ORD 기록
ord-8471144d668d4d5e888fb6ff29bf7a75
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09067929B2

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