Acryloyl chloride → 6-Acryloylaminonaphthalene-2-carboxylic acid

HRID 2178187노트

반응식

HRID 2178187 반응식
[NH2:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:12]([OH:14])=[O:13])[CH:8]=2)[CH:3]=1.[C:15](Cl)(=[O:18])[CH:16]=[CH2:17]>CN(C=O)C.N1C=CC=CC=1.O>[C:15]([NH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([C:12]([OH:14])=[O:13])[CH:6]=[CH:5]2)(=[O:18])[CH:16]=[CH2:17]

참가 물질

6

반응물 2

HCID 13140Acryloyl chlorideHCID 27339546-Aminonaphthalene-2-carboxylic acid

생성물 1

HCID 598604226-Acryloylaminonaphthalene-2-carboxylic acid수율 41.5%

시약·촉매·용매 3

HCID 962Water용매HCID 1049Pyridine용매HCID 6228Dimethylformamide용매

실험 절차

To a stirred solution of 2-Amino-6-naphthoic acid (0.3 g, 1.6 mmol) in DMF (2 mL) and pyridine (0.3 mL) was added at 0° C., acryloyl chloride (0.15 g, 1.6 mmol). The resulting mixture was allowed to come to rt and stirred further for 2 h. After that it was poured in water (5 mL) and the solid separated was filtered and dried under reduced pressure to get the desired product (160 mg, 41.5%) as a pale brown solid. This solid was used in the next step without further purification.

후처리

  1. customto come to rt
  2. customthe solid separated
  3. filtrationwas filtered
  4. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-140a690b740c4dbda54287fedaa014ed
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09067929B2

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