Lithium Hydroxide → 6-Bromo-3-hydroxypyridine-2-carboxylic acid

HRID 2178278노트

반응식

HRID 2178278 반응식
[Br:1][C:2]1[N:7]=[C:6]([C:8]([O:10]C)=[O:9])[C:5]([OH:12])=[CH:4][CH:3]=1.[Li+].[OH-]>CO>[Br:1][C:2]1[N:7]=[C:6]([C:8]([OH:10])=[O:9])[C:5]([OH:12])=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 3939Lithium HydroxideHCID 22175135Methyl 6-bromo-3-hydroxypicolinate

생성물 1

HCID 221751166-Bromo-3-hydroxypyridine-2-carboxylic acid

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Methyl 6-bromo-3-hydroxypicolinate (26B) (464 mg, 2 mmol) in MeOH (0.5 mL) was added to a solution of LiOH (200 mg in 2 mL water). The reaction mixture was stirred at rt for 2 h. The product precipitated out of solution and was filtered, washed with water, and dried under reduced pressure to provide the desired product 6-bromo-3-hydroxypicolinic acid (55A). 1H NMR (300 MHz, CDCl3): 7.6 (1H, d), 7.32 (1H, d).

후처리

  1. customThe product precipitated out of solution
  2. filtrationwas filtered
  3. washwashed with water
  4. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-02d113a9a0864c5aa00ff2521cf38f57
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09067928B2

반응 노트

불러오는 중…