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Water → (3 S)-1-[5-Chloro-3-[(4-methoxyphenyl)methyl]triazolo[4,5-d]pyrimidin-7-yl]pyrrolidin-3-ol

HRID 2179101
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HRID 2179101 반응식
[Cl:1][C:2]1[N:3]=[C:4](Cl)[C:5]2[N:10]=[N:9][N:8]([CH2:11][C:12]3[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][CH:13]=3)[C:6]=2[N:7]=1.CC[N:23]([CH:27]([CH3:29])C)[CH:24]([CH3:26])C.[OH2:30]>C(Cl)Cl>[Cl:1][C:2]1[N:3]=[C:4]([N:23]2[CH2:24][CH2:26][C@H:29]([OH:30])[CH2:27]2)[C:5]2[N:10]=[N:9][N:8]([CH2:11][C:12]3[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][CH:13]=3)[C:6]=2[N:7]=1
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참가 물질

5

반응물 3

HCID 962WaterHCID 81531DiisopropylethylamineHCID 582908695,7-dichloro-3-(4-methoxybenzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine

생성물 1

HCID 89587064(3 S)-1-[5-Chloro-3-[(4-methoxyphenyl)methyl]triazolo[4,5-d]pyrimidin-7-yl]pyrrolidin-3-ol

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A mixture of 5,7-Dichloro-3-(4-methoxy-benzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine (example 109, b) (2.95 g), (S)-pyrrolidinol (1.82 g, 20.9 mmol) and DIPEA (9.83 g, 76.1 mmol) in DCM was stirred at room temperature for 30 min. The mixture was poured into water, extracted with DCM and the combined organic layers were dried with MgSO4, filtered and evaporated to yield the crude title compound which was used in the consecutive step without further purification. MS (m/e): 361.3 (MH+).

후처리

  1. extractionextracted with DCM
  2. dry with materialthe combined organic layers were dried with MgSO4
  3. filtrationfiltered
  4. customevaporated

출처 및 근거

ORD 기록
ord-dfdd09f019c44b8bb346d2fcc95d22a0
출처 데이터셋
uspto-grants-2015_06
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09067943B2

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