Benzylamine → N-[4-(Methylthio)phenyl]benzenemethanamine

HRID 2179276

반응식

Br[C:2]1[CH:7]=[CH:6][C:5]([S:8][CH3:9])=[CH:4][CH:3]=1.[CH2:10]([NH2:17])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>>[CH2:10]([NH:17][C:2]1[CH:7]=[CH:6][C:5]([S:8][CH3:9])=[CH:4][CH:3]=1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

참가 물질

반응물 2

HCID 7504Benzylamine

HCID 660374-Bromothioanisole

생성물 1

HCID 9964622N-[4-(Methylthio)phenyl]benzenemethanamine수율 88%

실험 절차

Using the general procedure, 4-bromothioanisole (203 mg, 1.0 mmol) was coupled with benzylamine (164 μL, 1.5 mmol). Purification of the crude product by column chromatography on silica gel using hexane/ethyl acetate (15:1) as eluent afforded the desired product as a white solid (201 mg, 88% yield). Rf=0.4 (hexane/ethyl acetate=10:1).

후처리

customPurification of the crude product by column chromatography on silica gel

출처 및 근거

ORD 기록: ord-639a7cb68de8402a918f20d3f02831d7
출처 데이터셋: uspto-grants-2015_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09067955B2

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