Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetohydrazide → 6'-(2-Hydroxypropyl)-4'-methoxy-4-nitrobenzophenone acetylhydrazone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetohydrazide | HCID 14039 | — |
| 반응물 | 1-Hydroxy-3-methyl-1-(4-nitrophenyl)-6-methoxyisochroman | HCID 22488971 | — |
| 촉매 | Hydrochloric Acid | HCID 313 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 6'-(2-Hydroxypropyl)-4'-methoxy-4-nitrobenzophenone acetylhydrazone | HCID 86584470 | 66.3% |
반응 단계
To a solution of 4 (1.6 g) in 25 ml of ethanol was added acetic hydrazide (0.4 g) and 2 drops of concentrated HCl. The resulting solution was heated to reflux for 3 hours. The solvent was removed under reduced pressure. The residue was treated with NaHCO3, and extracted with ethyl acetate. The combined organic phase was washed with brine, dried over Na2SO4. Removal of the solvent gave the desired product (1.25 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06887867B2 |
| 출처 데이터셋 | uspto-grants-2005_05 |
| ORD ID | ord-a9a61f4ca8f04b30a8369b6436cc3cd4 |
| 출처 메모 | uspto-grants-2005_05 |