反应详情

To a solution of 4 (1.6 g) in 25 ml of ethanol was added acetic hydrazide (0.4 g) and 2 drops of concentrated HCl. The resulting solution was heated to reflux for 3 hours. The solvent was removed under reduced pressure. The residue was treated with NaHCO3, and extracted with ethyl acetate. The combined organic phase was washed with brine, dried over Na2SO4. Removal of the solvent gave the desired product (1.25 g).

1. temperatureThe resulting solution was heated
2. temperatureto reflux for 3 hours
3. customThe solvent was removed under reduced pressure
4. additionThe residue was treated with NaHCO3
5. extractionextracted with ethyl acetate
6. washThe combined organic phase was washed with brine
7. dry with materialdried over Na2SO4
8. customRemoval of the solvent