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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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Nitric Acid → [(4aR,6R,8aS)-2-amino-8a-(2-fluoro-5-nitrophenyl)-4,4a,5,6,8,8a-hexahydro-7-oxa-3-thia-1-azanaphthalen-6-yl]methanol

HRID 217992
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HRID 217992 반응식
S(=O)(=O)(O)O.[NH2:6][C:7]1[S:16][CH2:15][C@H:14]2[C@:9]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=3[F:25])([CH2:10][O:11][C@@H:12]([CH2:17][OH:18])[CH2:13]2)[N:8]=1.[N+:26]([O-])([OH:28])=[O:27].[OH-].[Na+]>C(O)(C(F)(F)F)=O>[NH2:6][C:7]1[S:16][CH2:15][C@H:14]2[C@:9]([C:19]3[CH:24]=[C:23]([N+:26]([O-:28])=[O:27])[CH:22]=[CH:21][C:20]=3[F:25])([CH2:10][O:11][C@@H:12]([CH2:17][OH:18])[CH2:13]2)[N:8]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 944Nitric AcidHCID 1118Sulfuric AcidHCID 14798Sodium HydroxideHCID 58406040[(4aR,6R,8aS)-2-amino-8a-(2-fluorophenyl)-4,4a,5,6,8,8a-hexahydro-7-oxa-3-thia-1-azanaphthalen-6-yl]methanol

생성물 1

HCID 58406109[(4aR,6R,8aS)-2-amino-8a-(2-fluoro-5-nitrophenyl)-4,4a,5,6,8,8a-hexahydro-7-oxa-3-thia-1-azanaphthalen-6-yl]methanol

시약·촉매·용매 1

HCID 6422Trifluoroacetic acid용매

실험 절차

Concentrated sulfuric acid (2.5 ml) was added dropwise to a solution of [(4aR,6R,8aS)-2-amino-8a-(2-fluorophenyl)-4,4a,5,6,8,8a-hexahydro-7-oxa-3-thia-1-azanaphthalen-6-yl]methanol (700 mg) in TFA (5 ml) in an ice bath. Then, fuming nitric acid (specific gravity: 1.52, 103 μl) was added dropwise at the same temperature, followed by stirring for one hour. The reaction mixture was poured into ice and made basic with a 5 N sodium hydroxide solution, followed by stirring at room temperature for two hours. The aqueous layer was extracted with dichloromethane, and the organic layer was dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to obtain the title compound (1.0 g).

후처리

  1. additionThe reaction mixture was poured into ice
  2. stirringby stirring at room temperature for two hours
  3. extractionThe aqueous layer was extracted with dichloromethane
  4. dry with materialthe organic layer was dried over anhydrous magnesium sulfate
  5. customThe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-51bd7574f6784e3795a2d39b89ce72a5
출처 데이터셋
uspto-grants-2012_06
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08198269B2

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