7-Benzyloxy-4-chloro-6-methoxycinnoline hydrochloride → 4-Chloro-7-hydroxy-6-methoxycinnoline

HRID 2180119

반응식

HRID 2180119 반응식
Cl.C([O:9][C:10]1[CH:19]=[C:18]2[C:13]([C:14]([Cl:20])=[CH:15][N:16]=[N:17]2)=[CH:12][C:11]=1[O:21][CH3:22])C1C=CC=CC=1>C(O)(C(F)(F)F)=O>[Cl:20][C:14]1[C:13]2[C:18](=[CH:19][C:10]([OH:9])=[C:11]([O:21][CH3:22])[CH:12]=2)[N:17]=[N:16][CH:15]=1

참가 물질

3

반응물 1

HCID 219910077-Benzyloxy-4-chloro-6-methoxycinnoline hydrochloride

생성물 1

HCID 1357525234-Chloro-7-hydroxy-6-methoxycinnoline수율 94%

시약·촉매·용매 1

HCID 6422Trifluoroacetic acid용매

실험 절차

A solution of 7-benzyloxy-4-chloro-6-methoxycinnoline hydrochloride (3.06 g, 9 mmol), in TFA (30 ml) was heated at reflux for 5 hours. After evaporation of the solvent, the residue was suspended in water and adjusted to pH7 with saturated aqueous sodium hydrogen carbonate solution. The resulting solid was filtered off, washed with water and ether and dried under vacuum to give 4-chloro-7-hydroxy-6-methoxycinnoline as a yellow solid (1.78 g, 94%).

후처리

  1. temperatureat reflux for 5 hours
  2. customAfter evaporation of the solvent
  3. filtrationThe resulting solid was filtered off
  4. washwashed with water and ether
  5. customdried under vacuum

출처 및 근거

ORD 기록
ord-0ab58c77ede44c7db135dbd692d651d1
출처 데이터셋
uspto-grants-2005_05
특허 번호
US06887874B2

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