Iodoethane → 1-(4-Isopropyl-7-ethoxy-2,2-dimethyl-2H-chromen-6-yl)ethanone

HRID 2180485노트

반응식

HRID 2180485 반응식
[OH:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([CH:14]([CH3:16])[CH3:15])=[CH:7][C:8]([CH3:13])([CH3:12])[O:9]2)=[CH:4][C:3]=1[C:17](=[O:19])[CH3:18].[CH2:20](I)[CH3:21].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH:14]([C:6]1[C:5]2[C:10](=[CH:11][C:2]([O:1][CH2:20][CH3:21])=[C:3]([C:17](=[O:19])[CH3:18])[CH:4]=2)[O:9][C:8]([CH3:13])([CH3:12])[CH:7]=1)([CH3:15])[CH3:16]

참가 물질

5

반응물 3

HCID 6340IodoethaneHCID 11430Potassium CarbonateHCID 224909177-Hydroxy-4-isopropyl-2,2-dimethyl-2H-chromen-6-yl-ethanone2회

생성물 1

HCID 224910471-(4-Isopropyl-7-ethoxy-2,2-dimethyl-2H-chromen-6-yl)ethanone

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

As described in General Procedure A, a solution of 1-(7-hydroxy-4 isopropyl-2,2-dimethyl-2H-chromen-6-yl)-ethanone (Compound 62, 205 mg, 0.69 mmol) in acetone were added ethyl iodide (0.3 mL, 3.45 mmol) and potassium carbonate (476 mg, 3.45 mmol) to give rise to the title compound as a colorless oil after purification by flash chromatography (silica gel, 5% ethyl acetate in hexanes).

출처 및 근거

ORD 기록
ord-14b050941e6a48f2a88d3abc76f81f9e
출처 데이터셋
uspto-grants-2005_05
특허 번호
US06887896B1

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