Water → Tolterodine

HRID 2180918

반응식

HRID 2180918 반응식
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([OH:24])=[C:6]([C@@H:8]([C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH2:9][CH2:10][N:11]([CH:15]([CH3:17])[CH3:16])[CH:12]([CH3:14])[CH3:13])[CH:7]=1.C(O)(C(O)=O)C(O)C(O)=O.O.C(=O)([O-])[O-].[Na+].[Na+].[OH-].[Na+]>C1(C)C=CC=CC=1>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([OH:24])=[C:6]([C@@H:8]([C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH2:9][CH2:10][N:11]([CH:12]([CH3:14])[CH3:13])[CH:15]([CH3:16])[CH3:17])[CH:7]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 10340Sodium CarbonateHCID 14798Sodium HydroxideHCID 9847786(R)-2-(3-(Diisopropylamino)-1-phenylpropyl)-4-methylphenol 2,3-dihydroxysuccinate

생성물 1

HCID 443879Tolterodine

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

Tolterodine tartrate (2.1 g) is mixed with water (45 ml) and toluene (2.5 ml). Sodium carbonate (800 mg) is added to the slurry. Sodium hydroxide (2.0 N, 1.5 ml) is added. The mixture is extracted three times with toluene (3 ml), saving the organic phase. Anhydrous potassium carbonate is added to the organic phase dissolve the tolterodine tartate, giving the title compound in solution.

후처리

  1. extractionThe mixture is extracted three times with toluene (3 ml)
  2. additionAnhydrous potassium carbonate is added to the organic phase
  3. dissolutiondissolve the tolterodine tartate

출처 및 근거

ORD 기록
ord-be8988cf4f904dc38f475ce707f7c13f
출처 데이터셋
uspto-grants-2005_05
특허 번호
US06890920B2

연결된 노트

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