Pyridine → Phenol, 3-chloro-4-methyl-, acetate

HRID 2181015

반응식

HRID 2181015 반응식
[C:1]([O:4][C:5](=[O:7])[CH3:6])(=O)[CH3:2].N1C=CC=CC=1.[Cl:14][C:15]1C=C(O)[CH:18]=[CH:19][C:20]=1[CH3:21]>CCOCC>[C:5]([O:4][C:1]1[CH:18]=[CH:19][C:20]([CH3:21])=[C:15]([Cl:14])[CH:2]=1)(=[O:7])[CH3:6]

참가 물질

5

반응물 3

HCID 1049PyridineHCID 7918Acetic AnhydrideHCID 148533-Chloro-4-methylphenol

생성물 1

HCID 538898Phenol, 3-chloro-4-methyl-, acetate수율 99.6%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

Acetic anhydride (430 mg) and pyridine (416 mg) were added to a solution of 3-chloro-4-methylphenol (500 mg) in ether (5.0 ml), and the mixture was stirred at room temperature for 2 hr. The reaction mixture was washed once with 1N hydrochloric acid and twice with saturated brine, dried over magnesium sulfate, and concentrated to dryness under reduced pressure to give 4-acetoxy-2-chlorotoluene as a pale-yellow oil (645 mg).

후처리

  1. washThe reaction mixture was washed once with 1N hydrochloric acid and twice with saturated brine
  2. dry with materialdried over magnesium sulfate
  3. concentrationconcentrated to dryness under reduced pressure

출처 및 근거

ORD 기록
ord-79eae0ab6e924be499d5289f2e5fa59c
출처 데이터셋
uspto-grants-2005_05
특허 번호
US06890934B2

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