Thionyl Chloride → 4-Pentenyl 5-aminolevulinate hydrochloride
반응식
S(Cl)([Cl:3])=O.Cl.[NH2:6][CH2:7][C:8](=[O:14])[CH2:9][CH2:10][C:11]([OH:13])=[O:12]>CN(C)C=O>[ClH:3].[NH2:6][CH2:7][C:8](=[O:14])[CH2:9][CH2:10][C:11]([O:13][CH2:11][CH2:10][CH2:9][CH:8]=[CH2:7])=[O:12]참가 물질
4
실험 절차
To 1 ml of thionyl chloride (SOCl2) were added 3 drops of N,N-dimethylformamide (DMF) with stirring. Following the addition of 5-aminolevulinic acid hydrochloride (ALA.HCl, 200 mg, 1.19 mmol), the solution was stirred for 12 hours at room temperature. Concentration in a vacuum was conducted before the addition of 4-pentenol. Then, the reaction mixture was stirred for 1.5 hours at room temperature, followed by purification by silica gel chromatography to afford 4-pentenyl 5-aminolevulinate hydrochloride at a yield of 47%.
후처리
- stirringthe solution was stirred for 12 hours at room temperature
- concentrationConcentration in a vacuum
- additionwas conducted before the addition of 4-pentenol
- stirringThen, the reaction mixture was stirred for 1.5 hours at room temperature
- customfollowed by purification by silica gel chromatography
출처 및 근거
- ORD 기록
- ord-0296379ca87344de8617cee42236c871
- 출처 데이터셋
- uspto-grants-2012_06
- 특허 번호
- US08198325B2
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