Methanol → 2-Bromoquinoline-4-carboxylic acid
반응식
[Br:1][C:2]1(C(OC)=O)[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[NH:3]1.[OH-:16].[Na+].[CH3:18][OH:19]>O>[Br:1][C:2]1[CH:11]=[C:10]([C:18]([OH:19])=[O:16])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1참가 물질
5
반응 조건
- 온도
- 50 °C
실험 절차
A mixture of methyl 2-bromoquinolinecarboxylate (7.2 g) and NaOH (1.1 g) in 15 mL of methanol and 15 mL of water is stirred at 50° C. until TLC indicates the disappearance of starting material. After cooling, the methanol is evaporated and the mixture is treated with 28 mL of 1N HCl, the solid is collected by filtration and dried to afford 6.1 g of 2-bromoquinoline-4-carboxylic acid.
후처리
- temperatureAfter cooling
- customthe methanol is evaporated
- additionthe mixture is treated with 28 mL of 1N HCl
- filtrationthe solid is collected by filtration
- customdried
출처 및 근거
- ORD 기록
- ord-b3a45560bfa14ac4b0d8b345f96c9eec
- 출처 데이터셋
- uspto-grants-2005_05
- 특허 번호
- US06894044B2
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