Sodium Hydroxide → HCID 69795151, 화합물

HRID 2181663노트

반응식

HRID 2181663 반응식
[NH2:1][C:2]([C:4]1[O:5][C:6]2[CH:12]=[C:11]([C:13]([O:15]C)=[O:14])[CH:10]=[CH:9][C:7]=2[CH:8]=1)=[O:3].[OH-].[Na+]>CO.O>[NH2:1][C:2]([C:4]1[O:5][C:6]2[CH:12]=[C:11]([C:13]([OH:15])=[O:14])[CH:10]=[CH:9][C:7]=2[CH:8]=1)=[O:3]

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 22481693HCID 22481693, 화합물

생성물 1

HCID 69795151HCID 69795151, 화합물수율 93%

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

반응 조건

온도
50 °C

실험 절차

Methyl 2-(aminocarbonyl)-1-benzofuran-6-carboxylate(164 mg, 0.75 mmol) is dissolved in MeOH (5 mL) and water (1 mL), treated drop-wise with 2N NaOH (450 μL, 0.9 mmol) and monitored by TLC. The volatiles are removed in vacuo, and the resulting tan solid is dissolved in water (5 mL) and acidified to pH 3 with concentrated HCl. The resulting solid is collected via filtration and dried in a vacuum oven with heat 50° C. to afford 142 mg (93%) of 2-(aminocarbonyl)-1-benzofuran-6-carboxylic acid as an orange solid. HRMS (EI) calcd for C10H7NO4: 205.0375, found 205.0378 (M)+.

후처리

  1. customThe volatiles are removed in vacuo
  2. dissolutionthe resulting tan solid is dissolved in water (5 mL)
  3. filtrationThe resulting solid is collected via filtration
  4. customdried in a vacuum oven

출처 및 근거

ORD 기록
ord-7aade1f6d7e34b47b9d9c483c4a4994f
출처 데이터셋
uspto-grants-2005_05
특허 번호
US06894042B2

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