Sodium Hydroxide → HCID 69794736, 화합물

HRID 2181667노트

반응식

HRID 2181667 반응식
[C:1]([C:4]1[O:5][C:6]2[CH:12]=[C:11]([C:13]([O:15]C)=[O:14])[CH:10]=[CH:9][C:7]=2[CH:8]=1)(=[O:3])[CH3:2].[OH-].[Na+]>CO.O>[C:1]([C:4]1[O:5][C:6]2[CH:12]=[C:11]([C:13]([OH:15])=[O:14])[CH:10]=[CH:9][C:7]=2[CH:8]=1)(=[O:3])[CH3:2]

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 22481734HCID 22481734, 화합물

생성물 1

HCID 69794736HCID 69794736, 화합물수율 93,124.703%

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

Methyl 2-acetyl-1-benzofuran-6-carboxylate (155 mg, 0.71 mmol) is dissolved in MeOH (3 ml) and H2O (0.5 ml). 2N NaOH (0.39 ml, 0.78 mmol) is added drop-wise, and the reaction is stirred overnight. The volatiles are removed in vacuo, and the residue is dissolved in H2O (3 ml). Concentrated HCl is used to adjust the pH to 3, and the resulting precipitate is isolated via filtration and dried overnight to afford 135 g (93%) of 2-acetyl-1-benzofuran-6-carboxylic acid as a yellow solid. MS for C11H8O4, (ESI−) m/z: 202.7 (M−H)−.

후처리

  1. customThe volatiles are removed in vacuo
  2. dissolutionthe residue is dissolved in H2O (3 ml)
  3. customthe resulting precipitate is isolated via filtration
  4. customdried overnight

출처 및 근거

ORD 기록
ord-88965b41741748a798df5bed403c52cc
출처 데이터셋
uspto-grants-2005_05
특허 번호
US06894042B2

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