Sodium Hydroxide → HCID 69795068, 화합물

HRID 2181668노트

반응식

HRID 2181668 반응식
[CH2:1]([O:3][CH:4]([O:18][CH2:19][CH3:20])[C:5]1[O:6][C:7]2[CH:13]=[C:12]([C:14]([O:16]C)=[O:15])[CH:11]=[CH:10][C:8]=2[CH:9]=1)[CH3:2].[OH-].[Na+]>CO.O>[CH2:19]([O:18][CH:4]([O:3][CH2:1][CH3:2])[C:5]1[O:6][C:7]2[CH:13]=[C:12]([C:14]([OH:16])=[O:15])[CH:11]=[CH:10][C:8]=2[CH:9]=1)[CH3:20]

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 22481729HCID 22481729, 화합물

생성물 1

HCID 69795068HCID 69795068, 화합물수율 103.4%

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

Methyl 2-(diethoxymethyl)-1-benzofuran-6-carboxylate (417 mg, 1.5 mmol) is dissolved in MeOH (8 ml) and H2O (2 ml). 2N NaOH (0.9 ml, 1.8 mmol) is added drop-wise, and the reaction is stirred for 4 days. The volatiles are removed in vacuo and the residue is dissolved in H2O (2 ml). Concentrated HCl is used to adjust the pH to 3, and the resulting precipitate is isolated via filtration and dried overnight to afford 410 mg (>100%, water present) of 2-(diethoxymethyl)-1-benzofuran-6-carboxylic acid as a brown solid. 1H NMR (400 MHz, CDCl3): δ 1.29, 3.72, 6.9, 7.66, 8.04, 8.29 ppm.

후처리

  1. customThe volatiles are removed in vacuo
  2. dissolutionthe residue is dissolved in H2O (2 ml)
  3. customthe resulting precipitate is isolated via filtration
  4. customdried overnight

출처 및 근거

ORD 기록
ord-dc04a162a7ca4bdaac9b5d1b589b17c0
출처 데이터셋
uspto-grants-2005_05
특허 번호
US06894042B2

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