Sodium Hydroxide → 3-Methyl-1-benzofuran-5-carboxylic acid
반응식
[CH3:1][C:2]1[C:6]2[CH:7]=[C:8]([C:11]([O:13]C)=[O:12])[CH:9]=[CH:10][C:5]=2[O:4][CH:3]=1.[OH-].[Na+]>CO.O>[CH3:1][C:2]1[C:6]2[CH:7]=[C:8]([C:11]([OH:13])=[O:12])[CH:9]=[CH:10][C:5]=2[O:4][CH:3]=1참가 물질
5
실험 절차
Methyl 3-methyl-1-benzofuran-5-carboxylate (365 mg, 1.9 mmol) is dissolved in MeOH (7 mL), diluted with H2O (3.5 mL) and treated with 3N NaOH (1.41 mL, 4.2 mmol). The mixture is diluted with MeOH (3.5 mL) to homogeneity, stirred at RT for 2.5 days then concentrated to dryness. The residue is dissolved in H2O (5 mL) and acidified to pH 2 with concentrated HCl. The resulting solid is filtered and dried in a vacuum oven at 40° C. for 18 h to afford 321 mg (95%) of 3-methyl-1-benzofuran-5-carboxylic acid as a white solid. HRMS (FAB) calcd for C10H8O3+H: 177.0552, found: 177.0553 (M+H)+.
후처리
- concentrationthen concentrated to dryness
- dissolutionThe residue is dissolved in H2O (5 mL)
- filtrationThe resulting solid is filtered
- customdried in a vacuum oven at 40° C. for 18 h
출처 및 근거
- ORD 기록
- ord-379062f285a94a91a6b87e4c0ba0ca87
- 출처 데이터셋
- uspto-grants-2005_05
- 특허 번호
- US06894042B2
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