Sodium Hydroxide → HCID 69361512, 화합물
반응식
[CH:1]([C:4]1[C:8]2[CH:9]=[C:10]([C:13]([O:15]C)=[O:14])[CH:11]=[CH:12][C:7]=2[O:6][CH:5]=1)([CH3:3])[CH3:2].[OH-].[Na+]>CO.O>[CH:1]([C:4]1[C:8]2[CH:9]=[C:10]([C:13]([OH:15])=[O:14])[CH:11]=[CH:12][C:7]=2[O:6][CH:5]=1)([CH3:3])[CH3:2]참가 물질
5
실험 절차
Methyl 3-isopropyl-1-benzofuran-5-carboxylate (1.20 g, 5.51 mmol) is dissolved in MeOH (20 ml) and water (4 ml), treated drop-wise with 2N NaOH (3.3 ml, 6.6 mmol) and stirred at RT for 2 days, then at 40° C. for 4 h. The volatiles are removed in vacuo, the residue is dissolved in water (10 ml) and the pH is adjusted to 3 with concentrated HCl. The resulting precipitate is isolated via filtration and dried overnight to afford 1.08 g (97%) of 3-isopropyl-1-benzofuran-5-carboxylic acid as a white solid. MS (ESI−) for C12H12O3 m/z: 203.0 (M−H)−.
후처리
- waitat 40° C. for 4 h
- customThe volatiles are removed in vacuo
- dissolutionthe residue is dissolved in water (10 ml)
- customThe resulting precipitate is isolated via filtration
- customdried overnight
출처 및 근거
- ORD 기록
- ord-872d0176cf8b4d5a9b4aa67f1eec1f3a
- 출처 데이터셋
- uspto-grants-2005_05
- 특허 번호
- US06894042B2
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