Sodium Hydroxide → 4-{[(S)-8-fluoro-6-methylphenanthridin-5(6H)-yl]sulfonyl}phenol

HRID 2181816노트

반응식

HRID 2181816 반응식
C(=O)([O:5][C:6]1[CH:11]=[CH:10][C:9]([S:12]([N:15]2[C@@H:28]([CH3:29])[C:27]3[C:22](=[CH:23][CH:24]=[C:25]([F:30])[CH:26]=3)[C:21]3[CH:20]=[CH:19][CH:18]=[CH:17][C:16]2=3)(=[O:14])=[O:13])=[CH:8][CH:7]=1)OCC.[OH-].[Na+]>CO>[F:30][C:25]1[CH:26]=[C:27]2[C:22](=[CH:23][CH:24]=1)[C:21]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[N:15]([S:12]([C:9]1[CH:8]=[CH:7][C:6]([OH:5])=[CH:11][CH:10]=1)(=[O:14])=[O:13])[C@H:28]2[CH3:29]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 69354951ethyl 4-{[(S)-8-fluoro-6-methylphenanthridin-5(6H)-yl]sulfonyl}phenyl carbonate

생성물 1

HCID 104742374-{[(S)-8-fluoro-6-methylphenanthridin-5(6H)-yl]sulfonyl}phenol수율 100%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

The title compound was prepared from ethyl 4-{[(S)-8-fluoro-6-methylphenanthridin-5(6H)-yl]sulfonyl}phenyl carbonate (0.05 g, 0.11 mmol), 2.5 N aqueous sodium hydroxide (2 mL, 5 mmol), and methanol (2 mL), according to the procedure and in the same manner as described in Example 32, Method A, Step e to yield 4-{[(S)-8-fluoro-6-methylphenanthridin-5(6H)-yl]sulfonyl}phenol as a solid (0.04 g, 100%), m.p. 193° C.;

출처 및 근거

ORD 기록
ord-73feb25e1c314137ac30796fffe942fc
출처 데이터셋
uspto-grants-2005_05
특허 번호
US06894061B2

반응 노트

불러오는 중…