Sodium Hydroxide → 2-(4-Bromophenyl)-2-methylpropanoic acid

HRID 218222노트

반응식

HRID 218222 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([CH3:15])([CH3:14])[C:9]([O:11]CC)=[O:10])=[CH:4][CH:3]=1.[OH-].[Na+]>O1CCCC1.CO>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([CH3:15])([CH3:14])[C:9]([OH:11])=[O:10])=[CH:6][CH:7]=1

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 11277257Ethyl 2-(4-bromophenyl)-2-methylpropanoate

생성물 1

HCID 109336792-(4-Bromophenyl)-2-methylpropanoic acid

시약·촉매·용매 2

HCID 887Methanol용매HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of the product of Example 22A (3.7 g, 13.6 mmoles) in tetrahydrofuran (110.0 ml) and methanol (37.0 ml) was added 2 N sodium hydroxide (19.0 ml) and the solution was stirred at ambient temperature for about 16 hours. The reaction mixture was concentrated in vacuum down to the water layer, was cooled with an ice bath, and was acidified by addition of 2N hydrochloric acid. The precipitate was filtered off and was dried in vacuum to provide the title compound.

후처리

  1. concentrationThe reaction mixture was concentrated in vacuum down to the water layer
  2. temperaturewas cooled with an ice bath
  3. additionwas acidified by addition of 2N hydrochloric acid
  4. filtrationThe precipitate was filtered off
  5. customwas dried in vacuum

출처 및 근거

ORD 기록
ord-e4fab534b8164ed0aefc0af450add9b5
출처 데이터셋
uspto-grants-2012_06
특허 번호
US08198331B2

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