Toluene → HCID 21948929, 화합물

HRID 2182698노트

반응식

HRID 2182698 반응식
[OH:1][CH2:2][C:3]1[CH:12]=[CH:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][C:9]=2[N+:13]([O-:15])=[O:14])[N:4]=1.[C:16](OC(=O)C)(=[O:18])[CH3:17].C1(C)C=CC=CC=1.CCCCCC.C(OCC)(=O)C>N1C=CC=CC=1>[C:16]([O:1][CH2:2][C:3]1[CH:12]=[CH:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][C:9]=2[N+:13]([O-:15])=[O:14])[N:4]=1)(=[O:18])[CH3:17]

참가 물질

6

반응물 4

HCID 1140TolueneHCID 7918Acetic AnhydrideHCID 4913360(5-Nitroquinolin-2-yl)methanolHCID 21226206Ethyl acetate hexane

생성물 1

HCID 21948929HCID 21948929, 화합물

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

A solution that consists of 390 mg (1.91 mmol) of 2-(hydroxymethyl)-5-nitroquinoline and 2.5 ml of acetic acid anhydride in 5.0 ml of pyridine is allowed to stir for 24 hours at room temperature. After repeated co-evaporation with toluene and subsequent chromatography on silica gel with hexane-ethyl acetate (0-100%), 410 mg (87% of theory) of the product is obtained.

후처리

  1. customis obtained

출처 및 근거

ORD 기록
ord-63f4651371584df4bb2c63e9f4aedbfc
출처 데이터셋
uspto-grants-2005_05
특허 번호
US06897224B2

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