Hydrogen Bromide → Benzaldehyde, 2,3-dihydroxy-4-nitro-

HRID 218271노트

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HRID 218271 반응식
C([O:4][C:5]1[C:12]([O:13]C)=[C:11]([N+:15]([O-:17])=[O:16])[CH:10]=[CH:9][C:6]=1[CH:7]=[O:8])(=O)C.Br>C(O)(=O)C>[OH:4][C:5]1[C:12]([OH:13])=[C:11]([N+:15]([O-:17])=[O:16])[CH:10]=[CH:9][C:6]=1[CH:7]=[O:8]

참가 물질

4

반응물 2

HCID 260Hydrogen BromideHCID 21783433HCID 21783433, 화합물

생성물 1

HCID 10442360Benzaldehyde, 2,3-dihydroxy-4-nitro-수율 91%

시약·촉매·용매 1

HCID 176Acetic Acid용매

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온도
150 °C

실험 절차

43 (2.5 g, 10.5 mmol) was added to a solution of acetic acid (62.5 mL) and hydrobromic acid 48% (70 mL) and the reaction mixture was heated at 150° C. for 4 h. The reaction mixture was then cooled to rt and evaporated to dryness. The residue was diluted in hot CH2Cl2 (40 mL) and filtered. The filtrate was evaporated to dryness to give 44 (1.74 g, 91%) which was used as such in the next step:

후처리

  1. temperatureThe reaction mixture was then cooled to rt
  2. customevaporated to dryness
  3. additionThe residue was diluted in hot CH2Cl2 (40 mL)
  4. filtrationfiltered
  5. customThe filtrate was evaporated to dryness

출처 및 근거

ORD 기록
ord-ff0c615cad7d4dd096e5f930998f45a0
출처 데이터셋
uspto-grants-2012_06
특허 번호
US08198302B2

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