Simazine → Butylamine

HRID 218278

반응식

HRID 218278 반응식
[CH:1]([N:4]([CH:7]([CH3:9])[CH3:8])[CH2:5][CH3:6])(C)C.[CH2:10]([NH:12][C:13]1[N:18]=[C:17]([NH:19][CH2:20][CH3:21])[N:16]=C(Cl)[N:14]=1)C.[CH3:23][C:24](N(C)C)=O>>[CH2:10]([NH2:12])[CH2:9][CH2:7][CH3:8].[CH2:7]([N:4]([CH2:5][CH3:6])[C:1]1[N:14]=[C:13]([NH2:12])[N:18]=[C:17]([NH:19][CH2:20][CH2:21][CH2:23][CH3:24])[N:16]=1)[CH3:9]

참가 물질

5

반응물 3

HCID 5216SimazineHCID 31374Dimethylacetamide2회HCID 81531Diisopropylethylamine

생성물 2

HCID 8007ButylamineHCID 53746588HCID 53746588, 화합물

반응 조건

온도
0 °C

실험 절차

A solution of 150 millimoles of n-butylamine in 50 ml of dimethylacetamide was prepared and cooled to 0° C. To this solution was added at 0° C. a solution of 250 millimoles of diisopropylethylamine and 50 millimoles of N,N′-diethyl-6-chloro-[1,3,5]triazine-2,4-diamine in 50 ml of dimethylacetamide, the resulting solution was heated under reflux for 4 hours, then cooled to room temperature, and the solvent was distilled off by an evaporator. The reaction mixture was then isolated and purified by silica gel column chromatography to give N,N-diethyl-N″-n-butyl-[1,3,5]triazine-2,4,6-triamine as an oily substance.

후처리

  1. temperaturethe resulting solution was heated
  2. temperatureunder reflux for 4 hours
  3. temperaturecooled to room temperature
  4. distillationthe solvent was distilled off by an evaporator
  5. customThe reaction mixture was then isolated
  6. custompurified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-2ce7375c1a764b80a4f996380fadf7b8
출처 데이터셋
uspto-grants-2012_06
특허 번호
US08198387B2

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