Hydrochloric Acid → 3-Chloro-o-cresol
반응식
Cl[C:2]12[O:8][CH:7]1[CH2:6][CH2:5][C:4](Cl)([Cl:9])[CH:3]2[CH3:11].Cl>CN(C=O)C>[Cl:9][C:4]1[C:3]([CH3:11])=[C:2]([OH:8])[CH:7]=[CH:6][CH:5]=1참가 물질
4
실험 절차
2 g (9.28 mmol) of epoxide 2h in solution in 5 cm3 of anhydrous DMF were heated to reflux for 3 h. The solution was acidified (pH=1) with 3N HCl, extracted with ether (4×25 cm3), dried over MgSO4, filtered and evaporated down. The crude product obtained was purified by flash chromatography on silica (eluent: ether/petroleum ether=5/95). 1.18 g of phenol 4e were obtained (macrobore GC purity>96%). The yield of compound 4e was 89%.
후처리
- temperatureto reflux for 3 h
- extractionextracted with ether (4×25 cm3)
- dry with materialdried over MgSO4
- filtrationfiltered
- customevaporated down
- customThe crude product obtained
- customwas purified by flash chromatography on silica (eluent: ether/petroleum ether=5/95)
출처 및 근거
- ORD 기록
- ord-1ac2c1865d0a4e33a67f9b64d9f725a8
- 출처 데이터셋
- uspto-grants-1995_06
- 특허 번호
- US05424460
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