Hydrochloric Acid → HCID 60004113, 화합물

HRID 2183466노트

반응식

HRID 2183466 반응식
C(OC(=O)[NH:7][C@H:8]([C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([NH:16][CH2:17][C:18]2[CH:19]=[N:20][CH:21]=[CH:22][CH:23]=2)[CH:11]=1)[CH3:9])(C)(C)C.Cl>O1CCOCC1>[NH2:7][C@H:8]([C:10]1[CH:11]=[C:12]([NH:16][CH2:17][C:18]2[CH:19]=[N:20][CH:21]=[CH:22][CH:23]=2)[CH:13]=[CH:14][CH:15]=1)[CH3:9]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 60004119HCID 60004119, 화합물

생성물 1

HCID 60004113HCID 60004113, 화합물수율 91.2%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

A mixture of (S)-(1-{3-[(pyridin-3-ylmethyl)-amino]-phenyl}-ethyl)carbamic acid tert-butyl ester (3 g) and 9 mL of 4 N HCl in dioxane (20 mL) was heated at 60° for 2 h. The reaction mixture was concentrated in vacuo, and the residue was neutralized with 10 N NaOH followed by extraction with methylene chloride. The organic layer was washed with brine, dried over Na2SO4, and concentrated in vacuo to give the title compound (1.9 g) as an oil.

후처리

  1. temperaturewas heated at 60° for 2 h
  2. concentrationThe reaction mixture was concentrated in vacuo
  3. extractionfollowed by extraction with methylene chloride
  4. washThe organic layer was washed with brine
  5. dry with materialdried over Na2SO4
  6. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-6db0c547b261404a9d82c04c483b7d84
출처 데이터셋
uspto-grants-2005_05
특허 번호
US06900210B2

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